Drug Discovery Technologies and Dependence on
ADME/TOX Screening
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May 4th, 2017
May 4th, 2017
The ADME/Tox screening market is the real
hurdle in modern drug discovery technologies as animal models cannot be
automated. Companies that develop state of art ADME/Tox screening products for
human relevance will generate greater revenues due to the product demand in the
market. Newer assays and new approaches to ADME/Tox screening are the demands
of pharmaceutical companies. Combinatorial chemistry and HTS are enabling
companies to test millions of drug compounds in lesser time frames.
Typically it takes about 10-12 years for a
drug to see the light of the market. Of about 10,000 compounds that are
screened, only about 2,000 pass through identification stage, of which about 10
enter preclinical testing and about 4.5 compounds to actual clinical testing,
finally the most befitting one enters the market post government board
approval. The procedure costs anything between US$500 million to US$1 billion.
The primary reason for drug removals from the
market is attributed to liver injuries. Drug approvals come under serious question
as there are drugs that are approved but then come under the gun due to their
negative consequences. For example, fenfluramine has been in the market for
many years and millions of patients have been subjected to this drug. It had to
be withdrawn after serious aftereffects. Traditional toxicity studies could not
predict troglitazone (an oral hypoglycemic agent), and Baycol, a statin, even
though drug interaction studies could have determined some. Animal models
depict human affinities better and can predict bone marrow and gastrointestinal
toxicities. However, other toxicities cannot be well predicted. Rodents predict
human toxicity the poorest, while dogs and monkeys show better results. But,
mice studies cost less while dogs and monkeys incur huge expenditures and are
restricted by availability.
What is Driving the ADME/TOX Market?
· Global ADME/TOX market is mainly driven by the
efforts of pharmaceutical and biotech companies for reducing time and cost of
drug discovery.
· ADME/Tox profiling of a drug candidate plays a
key role in reducing clinical trials cost and time of drug launch in the
market.
· ADME/Tox assays eliminate compounds with lack of
bioavailability, lower efficacy and toxicity in early stages, in order to save
time and costs in expensive later stages of drug discovery.
· Due to ethical issues and a growing trend towards
decrease in using animals in clinical trials, there is a gradual decline in
market for In vivo predictive technology.
· Though In vivo accounts for about three- fourth
of total ADME/Tox Technologies market currently, non-animal technologies - In
vitro and In silico are projected to peg more than 70% of the market.
· ADMET studies need to be
deployed early stage and the technology should be scalable to high throughput
formats. More and more companies are coming up with In silico approaches to
ADMET, and are automating and integrating assays to HTS.
For More Information
Gain comprehensive information on Global ADME/TOX
Technologies Market that
includes insights into products and services
used in the ADME/Tox market. Predictive technologies analyzed include In vivo,
In vitro, and In silico. Related technologies such as High Throughput Screening
(HTS), Laboratory Information Management System (LIMS), and cell based assays
are also analyzed. Market projections and estimates are illustrated
by region and by technology. The report serves as a guide to ADME/Tox market,
covering more than 350 companies that are engaged in ADME/Tox Market
size/screening, products and services. Major Contract Research Organizations,
Research Institutes and Universities serving the ADME/Tox market are also
covered in the corporate directory section of this report. Information related
to recent product releases, product developments, partnerships, collaborations,
and mergers and acquisitions is covered in the report. Compilation of Worldwide
Patents related to ADME/Tox Technologies is also provided. A global perspective
is presented along with regional analysis covering the regions of North
America, Europe, Asia-Pacific, Latin America, the Middle East and Africa with
93 exclusive graphically represented exhibits.
Why Buy this Report?
ADME/Tox
Technologies report is an
ideal research tool providing strategic business intelligence to the corporate
sector. This report may help strategists, investors, laboratories,
pharmaceutical companies, contract research organizations, companies and drug
approval authorities in –
¬ Gauging Competitive Intelligence
¬ Identifying Key Growth Areas and Opportunities
¬ Understanding Geographic Relevance to Product
¬ Knowing Regional Market Sizes and Growth Opportunities and
Restraints
¬ Keeping Tab on Emerging Technologies
¬ Equity Analysis
¬ Tapping New Markets
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